When using sprays or aerosols, excessive inhalation of some solvents (e.g. ACTIVE INGREDIENT: fipronil: 0.29%. For this reason it is significantly less toxic to mammals than to insects and other pests. The veterinary medicinal product is not intended for use in dogs. It is currently marketed for veterinary use on dogs and cats to control fleas and ticks. However, brief contact of the animal with water on one or two occasions within the month following application is unlikely to significantly reduce its efficacy. OTHER INGREDIENTS: 90.4%. Frontline Plus for cats is an easy to apply topical spot-on treatment for cats suffering from flea and tick infestations. Shelf life of the veterinary medicinal product as packaged for sale: 2 years. The frequency of adverse reactions is defined using the following convention: - very common (more than 1 in 10 animals treated displaying adverse reaction(s)), - common (more than 1 but less than 10 animals in 100 animals treated), - uncommon (more than 1 but less than 10 animals in 1,000 animals treated), - rare (more than 1 but less than 10 animals in 10,000 animals treated). The rationale for prescription should be tailored to the individual needs of the cat, based on clinical assessment, the animal's lifestyle and on the local epidemiological situation (including zoonotic risks, where relevant) in order to address exclusively situations of mixed infestations/risk of infestation. Acute reference dose for fipronil. is overexcited, which kills them rather quickly. Wear gloves when handling the veterinary medicinal product. in empty containers) in watercourses must be absolutely avoided. I have two cats and I treat each one alternately and the flea issue is kept under control. No data on the effect of bathing/shampooing on the efficacy of the product in cats is available. Fluralaner plus moxidectin was non-inferior to fipronil (P < 0.0001) at all assessments and superior to fipronil at 2 and 8 weeks for the proportion of cats free of ticks (P < 0.0001). Frontline plus shouldn’t be applied to kittens that are under 8 weeks of age. Therefore, epidemiological information about current susceptibility of the target species should be taken into account in order to limit the possibility of a future selection for resistance. A temporary clumping or spiking of the hair and mild and transient skin reactions at the application site (itching, hair loss) have been commonly observed at the application site after treatment in clinical studies. Special precautions to be taken by the person administering the veterinary medicinal product to animals. Parasite resistance to any particular class of antiparasitic drug may develop following frequent use of a compound of that class. Fipronil is also highly toxic to bees. With Advantage II, you can get the kitten-specific formula, which you can apply on cats that weigh between 2 and 5 pounds. For this reason disposal of fipronil residues (e.g. Correct application will minimise the occurrence of such events. DO NOT ALLOW YOUR CAT TO INGEST THIS PRODUCT. Date: Saturday, January 9, 2021 22:30, Broadline Spot-on Solution for Cats <2.5 kg and Broadline Spot-On Solution for Cats 2.5 - 7.5 kg, Broadline Spot-on Solution for Cats 2.5-7.5 kg. This causes hyperexcitation of contaminated insects' nerves and muscles. Fipronil's effects take about 24 hours to begin and last about 30 days. Transient salivation and/or vomiting could also be observed, in both kittens and adult cats, in isolated cases. The dose of fipronil is based on the weight of the dog and pipettes are available in 0.67 ml (for dogs up to 22 pounds), 1.34 ml (for dogs 23 to 44 pounds), 2.68 ml (for dogs 45 to 88 pounds) and 4 ml (for dogs 89 to 132 pounds). It works by interfering with the brain and spinal cord of insects, resulting in death. It also helps in the control of sarcoptic mange in dogs. Fipronil is a broad use insecticide that belongs to the phenylpyrazole chemical family. - Prevention of environmental flea contamination by inhibiting the development of flea immature stages (eggs, larvae and pupae) for over a month. As a precaution, it is not recommended to bathe animals within 2 days after topical treatment. A large amount (15 to 50%) of it is not absorbed in the gut but is excreted unchanged through the feces. Read the article on fipronil safety in this site. Once applied, Frontline flea treatment causes hyperexcitation and this will mean that you will notice more fleas on your animal. Amounts to be administered and administration route. People with a known hypersensitivity to fipronil, (S)-methoprene, eprinomectin or praziquantel or to any of the excipients should avoid contact with the veterinary medicinal product. Absorption of topically administered fipronil is rather low in dogs and cats, usually not more than 5% of the administered dose. - very rare (less than 1 animal in 10,000 animals treated, including isolated reports). INERT INGREDIENTS: 99.71%. Spot-on solution. Any unused veterinary medicinal product or waste material derived from it should be disposed of in accordance with local requirements. For cats with or at risk from mixed infestations by cestodes, nematodes and ectoparasites. Dosage: The recommended minimum doses are 10 mg/kg bodyweight for fipronil, 12 mg/kg for (S)-methoprene, 0.5 mg/kg for eprinomectin and 10 mg/kg for praziquantel. Save 5% more with Subscribe & Save . Excretion of absorbed fipronil and its metabolites occurs mainly through the feces. Do not use in cases of hypersensitivity to the active substances or to any of the excipients. If you intend to use a veterinary drug containing this active ingredient you must carefully read and follow the safety instructions in the product label. The dose is 0.0305ml/pound. TOTAL: 100.0% . The use of the veterinary medicinal product should exclusively be based on the confirmed mixed infestations or significant risk of such mixed infestations with ectoparasites and nematodes (including for heartworm disease prevention), and where concurrent treatment against cestodes is indicated. WHO Acute Hazard classification of pesticides: Class II, moderately hazardous. It has also been confirmed in healthy adult cats treated 3 times at two-week intervals with up to 5 times the recommended dose. Fipronil. CAUTION. Nevertheless, no this regarding guarantee is given, and any liability on its accuracy, integrity, sufficiency, actuality and opportunity is denied. is undertaken. 99 $32.99 $32.99. ducks). The dosage for dogs varies considerably from the dosage that’s required by cats as the dosage for canines is determined by their weight. up to 15 times the recommended dose) in healthy kittens aged 7 weeks and older treated up to 6 times at four-week intervals. If eye irritation persists or if side effects are noted, seek medical advice and show the package leaflet or the label to the physician. Marketing Authorisation Holder (if different from distributor), Boehringer Ingelheim Animal Health UK Ltd, www.boehringer-ingelheim.co.uk/­animal-health/­animal-health. Acute Toxicity and Tolerance of Fipronil. Select the appropriate applicator size for the weight of the cat. 4.2 out of 5 stars 4,077. Unused applicators must be stored in the intact blister package. The EU has recently banned the use of fipronil as a pesticide in certain crops because it is suspected to be associated with the Bee Colony Collapse Disorder. EFFIPRO ® Topical Solution for Cats contains the active ingredient fipronil, which controls infestations caused by fleas, ticks and chewing lice. Oral ingestion of the veterinary medicinal product resulted in common to uncommon vomiting, hyper-salivation and/or in transient neurological signs such as ataxia, disorientation, apathy and pupil dilation in safety studies. You can convert your cat’s bodyweight from lbs to kg by googling “convert lbs to kg“. Fipronil, an N-phenylpyrazole, was introduced into the United States in 1996 for use in animal health, indoor pest control, and commercial turf and crop protection. Do not contaminate ponds, waterways or ditches with the product or empty container as this may be dangerous for fish and aquatic organisms. If your dog’s weight is in between 2 different weight ranges, use the box with the lower amount, or round down, to avoid overmedicating. Be aware that the safety instructions for the same veterinary medicine may vary from country to country. Mild and transient neurological signs such as ataxia, disorientation, apathy and pupil dilation may be observed, with spontaneous recovery the day after. Safety has been demonstrated with up to 5 times the maximum exposure dose (i.e. Avoid contact with the cat's eyes. After treatment with BROADLINE, ticks will generally be killed within 48 hours after infestation without having a blood meal. Avoid contact of the applicator content with the fingers. SAFETY. Printed from NOAH Compendium (http://www.noahcompendium.co.uk). : Never use on cats pipettes approved only for dogs. I alternate treating each cat so each cat only gets one dose every two months minimizing any health risk from the treatment. In addition, the insect growth inhibitor s-methoprene kills flea eggs and larvae and thus disrupts the life cycle of ticks and fleas. View the full product label for application information. Is fipronil the most effective flea treatment? Frontline Plus for Cats . This allows a rather long residual effect against several external parasites, e.g. use on a particular host at a specific dose and against a specific parasite . Finished products contain one or more active ingredients, but also other ingredients that can be relevant from the safety point of view. Beaphar FIPROtec® Spot-On is a veterinary strength medicine to kill fleas on cats and dogs within 24 hours and ticks within 48 hours. In case of massive flea infestation and at the beginning of the control measures, these areas should be treated with a suitable environmental product and then vacuumed regularly. Fleas are all-too-common visitors to both cats and dogs. MSDSs target safety during manufacturing, transport, storage and handling of such materials. Our vet says: You should never ever apply dog spot on treatments to cats, or to any animal other that what it is intended for. - The product can be used as part of a treatment strategy for the control of flea allergy dermatitis (FAD). 640 mg/kg LD50 acute, chicken, p.o. Fipronil spray for dogs. - Treatment and prevention of infestations by fleas (. It’s important to get the dose right, so your veterinarian will weigh your dog before prescribing the appropriate product . FREE Shipping by Amazon. The primary metabolite is the sulfone derivative, which is substantially more toxic, both for parasites and for mammals. The nervous system of exposed parasites (fleas, ticks, mites, etc.) Echinococcosis represents a hazard for humans, and is a notifiable disease to the World Organisation for Animal Health (OIE). Transitory blindness or impaired vision have been observed in very rare cases based on post marketing safety experience. Cats in areas endemic for heartworm, or those which have travelled to endemic areas, may be infected with adult heartworms. In the absence of risk of co-infestation, the use of a narrow spectrum parasiticide should be considered as a first line therapy. The answer is NO, or else, you are going to risk your cat’s life. The toxicity of an active ingredient must not be confused with the toxicity of finished products, in this case parasiticidal drugs or pesticides. Laboratory studies with the individual ingredients in rats and rabbits have not produced teratogenic, foetotoxic or maternotoxic effects. KEEP OUT OF REACH OF CHILDREN. Fipronil is also formulated as insect bait for roaches, ants and termites; as sprays for pets; and as a granular turf product to control mole crickets. Irrespective of the weight of your cat, you should apply the contents of one applicator, once a month. Symptomatic treatment can be required if the signs do not resolve spontaneously within 24 hours. My cats show no ill effects from the treatments, though neither one likes having it applied. Active Ingredient. Do not inject, do not administer orally or via any other route. Cats infected with adult heartworms tolerated up to 3 times the maximum exposure dose (i.e. The safety of the veterinary medicinal product has not been established during pregnancy and lactation. Medication should never be administered without first consulting your veterinarian. Fipronil can be slightly irritant for the skin and the eyes. Fipronil (brand names: Frontline®, Barricade®, Easyspot®, Effipro®, Sentry Fiproguard®, Parastar®, PetArmor®, Pronyl OTC®, Spectra Sure®, and many others) is a topical medication used to treat fleas, ticks, and chewing lice infestations in dogs and cats. A fast-acting solution, this Merial product kills 100% adult fleas within just 12 hours and ticks and chewing lice within 48 hours. 9.6%. Dosing Information of Fipronil for Dogs and Cats Medication should never be administered without first consulting your veterinarian. The absorbed fipronil is found predominantly in fatty tissues. This way, it’s harder for them to lick off. For Dogs, Puppies, Cats and Kittens. Fipronil is highly toxic to some birds (e.g. Fipronil is highly toxic to fish and aquatic invertebrates. Do not use in sick or convalescent animals. Fipronil is almost insoluble in water. Clear colourless to yellow to red/brown solution. Side effects and overdose are very rare. Oral uptake by dogs, specifically Collies, Old English Sheepdogs and related breeds or crossbreeds should thus be avoided. Get it as soon as Wed, Dec 16. In case of dermal exposure rinse the skin with abundant water and soft detergents. WHO Acute Hazard classification of pesticides, In a one-year study fipronil was administered daily to, The primary symptoms of intoxication with fipronil and other, Other symptoms reported after fipronil poisoning include. Fipronil is an insecticide that disrupts the insect central nervous system which then causes them to die. Fipronil is a broad-spectrum insecticide that belongs to the phenylpyrazole chemical family. (c) Copyright NOAH Compendium 2021. Use only according to the benefit-risk assessment by the prescribing veterinarian. Do not smoke, drink or eat during application. Muscle tremors have been reported in very rare cases based on post marketing safety experience. Fipronil is used in a wide variety of pesticide products, including granular products for grass, gel baits, spot-… Contains Fipronil, the active ingredient used in Frontline Top Spot ... DO NOT EXCEED RECOMMENDED DOSAGE AMOUNT FOR CATS. In case of accidental eye exposure flush the eyes thoroughly with water, as the product can cause slight mucous membrane and eye irritation. Always ask your veterinary doctor, or pharmacist, or contact the manufacturer. Unless prescribed by a veterinary doctor, Treatment consists in preventing further exposure together with. This safety summary is a complement to the information on product labels and MSDS. chicken) but not to other ones (e.g. The rest is absorbed into blood and is partially metabolized. Besides erroneous dosing, overdosing can occur due to. fleas and ticks. Stored applicators must be kept in the intact blister package. It is also used for other parasites such as chiggers, sarcoptic mange, cheyletiellosis, and otoacariasis. Treatment should not be extrapolated from one animal to the other without veterinary opinion. It is important to apply the veterinary medicinal product to a skin area where the cat cannot lick it off: on the neck, in between shoulders. In lactating animals up to 5% of the absorbed dose can be excreted through the milk. Spot-on application only. For example, if your dog weighs 22.5 pounds, use the 5 to 22 pound box. This product is used in both dogs and cats. Treatment should not be extrapolated from one animal to the other without veterinary opinion. KEEP OUT OF REACH OF CHILDREN. Excipient: Butylhydroxytoluene (E321) 1 mg/ml. Other animals living in the same household should also be treated with a suitable product. Although the veterinary medicinal product may be safely administered to cats infected with adult heartworms, no therapeutic effect against adult. … Fipronil is used to control ants, beetles, cockroaches, fleas, ticks, termites, mole crickets, thrips, rootworms, weevils, and other insects. Fipronil is quite stable in soils, with a half-life of ~125 days. - Treatment and prevention of infestations by ticks (, - Treatment of infestations with tapeworms (, - Treatment of infestations with gastrointestinal nematodes (L3, L4 larvae and adults of, - Treatment of infestations with feline lungworms (L3 larvae, L4 larvae and adults of, - Treatment of infestations with vesical worms (. Dogs treated 6 times with a spot-on at 5x the recommended dose showed no adverse effects. The Meeting allocated an acute reference dose of 0.003 mg/kg bw for both fipronil and fipronil-desulfinyl on the basis of the NOAEL of 0.3 mg/kg bw per day in a study of neurotoxicity in rats given repeated doses of fipronil, and a safety factor of 100. All information in this site is made available in good faith and following a reasonable effort to ensure its correctness and actuality. Cardboard box containing applicators of 3 x 0.3 ml, 15 x 0.3 ml, 3 x 0.9 ml and 6 x 0.9 ml. 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Especially children both kittens and adult cats treated 3 times at two-week intervals with up 15... Containers ) in watercourses must be stored in the blister package treated with a half-life of ~125 days FAD.... If this occurs, wash off with soap and water of fipronil dogs. Applicator content with the fingers FIPROtec® spot-on is a white powder with a half-life of days.